The Rheumatoid Factor Test is often the first test ordered when rheumatoid arthritis (RA) is suspected. Although both RA and Sjogren’s syndrome can be diagnosed based on clinical signs and symptoms, this test can help distinguish between types of arthritis and other conditions that produce similar symptoms (joint pain, stiffness, and inflammation, among others). A CCP Blood Test may also be ordered to confirm an RA diagnosis, particularly if the RF test is negative.
Interpretation of test results should be made in conjunction with the patient’s symptoms. A positive result with high concentrations of RF along with signs and symptoms of either RA or Sjogren’s syndrome generally indicate presence of the respective condition. However, a negative Rheumatoid Factor Test does not rule out these conditions, and positive tests can occur in healthy patients and in those with a variety of other conditions.